Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the framework and dynamics of chromosomes. Our analysis interests involve:

You regularly get entangled in discussions about science and religion. You've also penned many guides on the subject. Don’t you think that in some unspecified time in the future We are going to know every little thing Which God’s function are going to be above?

, Groningen scientists current the final results in their initiatives to help make labs more sustainable and supply tips for other labs. 

Non-equilibrium folding of particular person DNA molecules recaptured as many as one thousand occasions in a stable state nanopore

To look through Academia.edu and the wider World wide web more quickly and even more securely, make sure you take a couple of seconds to upgrade your browser.

The coiled-coil from the human Rad50 DNA mend protein includes unique segments of enhanced versatility

We use nanofabricated microfluidic buildings to sample spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which assess the elemental position of spatial confinement in the molecular and mobile degree. Our projects include things like the next:

Nanopores represent a sublime and multipurpose Software to evaluate one molecules. We exploration novel detection modes with good-point out nanopores together with different methods to evaluate proteins with nanopores. Assignments encompass the following:

‘You should not just consider the concerns of tomorrow, but additionally think about the queries from the day after tomorrow’

‘The fantastically refined way where aspects in nature function hardly ever ceases to amaze me. If we clear up the puzzle of how daily life came into remaining, I be expecting that my amazement with the complexity of creation should have greater and with it my awe to the greatness of the Creator.’

Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim on the pore is highlighted in crimson, along with a 3D rendering of the movement in the DNA rod is displayed.

1999, first measurement in the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for a new Luttinger description of interacting electrons in nanotubes

Such as, we consider the nucleopore elaborate, a gateway among the mobile nucleus and the cytoplasm. This is an extremely sophisticated program and as a consequence hard to review in a cell, so we use biomimetics. We reconstruct holes and afterwards insert specific elements with the nucleopore complicated to review transportation by way of it at The one-molecule level.’

2013, managed shaping of Are living bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations ceesdekker.net inside the handedness of histone tetrasomes